Why has my doctor given me prasugrel?

You have been given prasugrel after having a heart attack to reduce the chances of having a further heart attack or stroke. Following a
heart attack, prasugrel is usually taken combined with aspirin for 1 year, after which you will continue aspirin for life. Check with your
doctor or pharmacist if you are still not sure why you need prasugrel.

How does it work?

Prasugrel belongs to a group of medicines called antiplatelets which help prevent blood clots forming in the bloods vessels which feed the
brain and heart muscle. Clots can block these vessels causing a heart attack or stroke. This is especially important if you have had a stent
fitted, as the chances of a blood clot forming inside the stent are much higher during the first year.

'Prasugrel and aspirin work in a slightly different way to stop platelets forming blood clots, meaning that two can work more effectively together.

How should I take prasugrel?

Always follow the instructions on the label. However, it is usual to take prasugrel once a day together with low dose aspirin. Do not stop
taking this medicine without talking to your doctor.

What are the side-effects of prasugrel?

All medicines have side-effects, but not everyone will experience them.

Because antiplatelet medicines reduce the ability of the blood to clot, it means that you may be more prone to nosebleeds, bruising or bleeding for longer than usual if you cut or injure yourself and heavier periods. 

This is normal, and usually an acceptable side effect because of the reduction in your risk of having a heart attack. You should tell your
doctor promptly if you experience uncontrollable bleeding (from a cut, for example), blood in your urine, bleeding from your rectum, blood in
your stools or black stools. 

Can I take other medicines with prasugrel?

Yes, but some other medicines can interact with prasugrel. It is important that you check with your doctor or pharmacist before taking
any other medicines including those that you buy over the counter.

Avoid taking cold and flu remedies that contain aspirin. Ibuprofen should generally be avoided if you are prescribed clopidogrel due to
the increased risk of bleeding. A suitable alternative for pain relief is paracetamol.

This leaflet is not a substitute for any advice your doctor, nurse or pharmacist may give you.

More detailed information can be obtained from the manufacturer’s information leaflet.

Pharmaceutical Service January 2022
Last Reviewed June 2025
Review Date June 2027