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Heart Surgery Team Interventional Cardiology ACHD Heart Rhythm Cardiac Imaging Community Cardiology Hypertension Aortic Surgery Team Thoracic Surgery Team Anaesthesia and Post-Op Pain Management Team Respiratory Medicine Team Radiology and Imaging Team Clinical Geneticist Clinical Psychologist

Mr Gopal Soppa

Consultant Cardiac & Mital Surgeon

Contact Details

Personal Assistant

Ellie Hatton-Daly

Tel: 0151 254 3255

Email: Ellie.Hatton-Daly@lhch.nhs.uk

FRCS (CTh), PhD                                              
Consultant Cardiac & Mital Surgeon

 

Area of Practice       

  • Adult Cardiac Surgery
     

Special Clinical Interests   

  • Valve surgery (with an interest in Mitral Valve Repair and Sutureless Valves)
  • Minimal Access Surgery
  • Surgery for Atrial Fibrillation
  • Arterial Revascularisation
  • Training & Research
     

Research Interests   

  • Improving clinical outcomes
  • Quality of Life after surgery
     

Current Membership of Professional Regional and National Bodies  

  • Royal College of Surgeons of England
  • Society for Cardiothoracic Surgery in Great Britain and Ireland
  • British Medical Association
  • Medical Defense Union
     

Languages Spoken   

  • English
  • Telugu
  • Hindi
     

Why choose LHCH?             

One of the largest heart and lung specialist centre in UK with a commitment to be the best and deliver outstanding ‘patient centred’ heart and chest care and research. It has been rated as the best by our patients, 8 times in the last 10 years. With the introduction of new techniques, LHCH will be the only centre in UK that will provide the complete range of surgical and interventional treatment procedures for the entire spectrum of mitral valve disease.
 

Training and Education

  • May 2001 MRCS – Edinburgh
  • June 2001 MRCS – England
  • October 2009 PhD (Imperial College London)
  • October 2015 FRCS (CTh)


About You

Married with 2 children, music, motorcycling, astronomy, cooking

 

Publications  

1. Minimally invasive approaches. Gopal K R Soppa, Anthony C de Souza. Key Topics in Cardiac Surgery, 2nd Edition, Editors: Ohri S, Moorjani N, Tang A; 2nd edition, August 2013, Hamtun Publishing. ISBN-10: 0957507305, ISBN-13: 978-0957507302.

2. Valve-sparing Aortic Root Replacement (Yacoub Remodelling Technique). Gopal Soppa, Rajdeep Bilkhu, Marjan Jahangiri; Essentials of Operative Cardiac Surgery, 2nd Edition, Editor: Prakash P Punjabi, Springer Print ISBN: 9783031145568, 3031145569, eText ISBN: 9783031145575, 3031145577


Original articles – Published as first author

1. Variation between hospitals in outcomes following cardiac surgery in the UK. Soppa G, Theodoropoulos P, Bilkhu R, Harrison DA, Alam R, Beattie R, Bleetman D, Hussain A, Jones S, Kenny L, Khorsandi M, Lea A, Mensah K, Hici TN, Pinho-Gomes AC, Rogers L, Sepehripour A, Singh S, Steele D, Weaver H, Klein A, Fletcher N, Jahangiri M. Ann R Coll Surg Engl. 2019 Mar 11:1-9. doi: 10.1308/rcsann.2019.0029.

2. Trainees Can Learn Minimally Invasive Aortic Valve Replacement Without Compromising Safety. Soppa G, Yates M, Viviano A, Smelt J, Valencia O, van Besouw JP, Jahangiri M. Interactive Cardiovascular and Thoracic Surgery, 2015; 20(4): 458-62.

3. Sutureless Valves in Aortic Stenosis. Soppa G, Jahangiri M (Letter to the Editor). The Journal of Thoracic and Cardiovascular Surgery, 2014; 148(1):364.

4. High volume practice by a single specialized team reduces mortality and morbidity of elective and urgent aortic root replacement. Soppa G, Abdulkareem N, Smelt J, Van Besouw JP, Jahangiri M. AORTA, 2013; 1(1):40-44.

5. Functional status and survival after prolonged intensive care unit stay following cardiac surgery. Soppa G, Woodford C, Yates M, Shetty R, Moore M, Valencia O, Fletcher N, Jahangiri M. Interactive Cardiovascular and Thoracic Surgery, 2013; 16(6):750-4.

6. Early experience with the transaortic approach for transcatheter aortic valve implantation. Soppa G, Roy D, Brecker S, Jahangiri M. The Journal of Thoracic and Cardiovascular Surgery, 2012; 143(5):1225-7.

7. Prolonged mechanical unloading reduces myofilament sensitivity to calcium and sarcoplasmic reticulum calcium uptake leading to contractile dysfunction. Soppa GK, Lee J, Stagg MA, Siedlecka U, Youssef S, Yacoub MH, Terracciano CMN. The Journal of Heart and Lung Transplantation, 2008; 27(8):882-9.

8. Role and possible mechanisms of clenbuterol in enhancing reverse remodelling during mechanical unloading in murine heart failure. Soppa GK, Lee J, Stagg MA, Felkin LE, Barton PJR, Siedlecka U, Youssef S, Yacoub MH, Terracciano CMN. Cardiovascular Research, 2008; 77(4), 695-706.

9. LVAD-induced molecular changes in the failing myocardium. Soppa GK, Barton PJR, Terracciano CMN, Yacoub MH. Invited Review, Current Opinion in Cardiology, 2008; 23(3):206-218.

10. Effects of chronic administration of clenbuterol on function and metabolism of adult rat cardiac muscle. Soppa GK, Smolenski RT, Latif N, Yuen AHY, Malik A, Karbowska J, Kochan Z, Terracciano CMN, Yacoub MH. American Journal of Physiology-Heart and Circulatory Physiology, 2005; 288(3):H1468-76.

Original articles – Published as co-author

1. Aortic valve replacement: same operation, same outcomes but a smaller incision. Harky A, Chan J, Soppa G, D Muir A. European Journal of Cardiothoracic Surgery, 2022 Dec 2;63(1):ezac585.

2. Accessing the mitral valve: single-chamber or double-chamber technique? Harky A, Chan JSK, Satti DI, Soppa G. European Journal of Cardiothoracic Surgery, 2022 Jul 11;62(2):ezac368

3. Adipocyte-derived relaxing factor-a fat load to be learnt. Harky A, Chan JSK, Hui JMH, Soppa G. European Journal of Cardiothoracic Surgery, 2022 May 27;61(6):1430-1431

4. A combined approach to correct posterior left ventricular aneurysm, aortic stenosis and coronary artery disease. Patel AJ, Mohamed S, Iqbal Y, Kar A, Soppa G. Journal of Surgical Case Reports, 2020 Oct 12;2020(10):rjaa356. doi: 10.1093/jscr/rjaa356. eCollection 2020 Oct.

5. Novel Approach to Repairing a Traumatic Aortic Arch Pseudoaneurysm Following a Fall. Hussain A, Youssefi P, Soppa G, Jahangiri M., AORTA 2019 Feb;7(1):15-17. doi: 10.1055/s-0039-1687902. Epub 2019 Jul 22.

6. The influence of prolonged intensive care stay on quality of life, recovery, and clinical outcomes following cardiac surgery: A prospective cohort study. Diab M, Bilkhu R, Soppa G, Edsell M, Fletcher N, Heiberg J, Royse C, Jahangiri M. Submitted to The Journal of Thoracic and Cardiovascular Surgery, 2018 Nov;156(5):1906-1915.e3. doi: 10.1016/j.jtcvs.2018.05.076. Epub 2018 Jun 5.

7. Fate of the Aortic Arch Following Surgery on Aortic Root and Ascending Aorta in Bicuspid Aortic Valve. Bilkhu R, Youssefi P, Soppa G, Theodoropoulos P, Phillips S, Liban B, Child A, Tome M, Nowell J, Sharma R, Edsell M, Jahangiri M. The Annals of Thoracic Surgery. 2018 Apr 23. pii: S0003-4975(18)30548-4

8. Analysis of aortic area/height ratio in patients with thoracic aortic aneurysm and type A dissection. Acharya M, Youssefi P, Soppa G, Valencia O, Nowell J, Kanagasabay R, Edsell M, Morgan R, Tome M, Jahangiri M. European Journal of Cardio-Thoracic Surgery. 2018, doi:10.1093/ejcts/ezy110.

9. Quality of life in relation to length of intensive care unit stay after cardiac surgery. Diab M, Bilkhu R, Soppa G, McGale N, Hirani SP, Newman SP, Jahangiri M. Journal of Cardiothoracic and Vascular Anesthesia. 2017, Jun;31(3):1080-1090.

10. Aortic Root Surgery: Does high surgical volume and a consistent perioperative approach improve outcome? Bilkhu R, Youssefi P, Soppa G, Sharma R, Child A, Edsell M, van Besouw JP, Jahangiri M. Seminars in Thoracic and Cardiovascular Surgery, 2016 Summer;28(2):302-309.

11. A Survey of Cardiothoracic Surgical Training in UK: Realities of a 6-year integrated Training Program. Smelt J, Soppa G, Nowell J, Barnard S, Jahangiri M. The Annals of Thoracic Surgery, 2015;100: 2314-9.

12. Soft plastic snugger to assist seating of prosthetic aortic valve. Smith DJ, Soppa G, Yates MT. The Annals of The Royal College of Surgeons of England, 2015; 97(3):244.

13. Circulating tumour cells in patients with lung cancer undergoing endobronchial cryotherapy. Chudasama D, Rice A, Soppa G, Anikin V. Cryobiology, 2015; 71(1):161-3.

14. Circulating Tumour Cells in Patients with Malignant Lung Tumors Undergoing Radio-frequency Ablation. Chudasama D, Rice A, Anikin V, Soppa G, Dalal P. Anticancer Research, 2015; 35(5):2823-6.

15. Perioperative Management and Outcomes of Aortic Surgery During Pregnancy. Yates MT, Soppa G, Smelt J, Fletcher N, van Besouw JP, Thilaganathan B, Jahangiri M. The Journal of Thoracic and Cardiovascular Surgery, 2015; 149:607-10.

16. Incidence and mechanisms of cerebral ischemia following transcatheter aortic valve implantation compared with surgical aortic valve replacement. Alassar A, Soppa G, Edsell M, Rich P, Roy D, Chis Ster I, Joyce R, Valencia O, Barrick T, Howe F, Moat N, Morris R, Markus H, Jahangiri M. The Annals of Thoracic Surgery, 2015, 99(3):802-8.

17. Impact of combined clenbuterol and metoprolol therapy on reverse remodelling during mechanical unloading. Navaratnarajah M, Siedlecka U, Ibrahim M, van Doorn C, Soppa G, Gandhi A, Shah A, Kukadia P, Yacoub M, Terracciano C. PLoS One, 2014; 9(9):e92909.

18. What is the optimal revascularization technique for isolated disease of the left anterior descending artery: minimally invasive direct coronary artery bypass or percutaneous coronary intervention? Patel AJ, Yates MT, Soppa GK. Interactive CardioVascular and Thoracic Surgery, 2014; 19(1):144-8.

19. Spontaneous coronary artery dissection in a 38 year old: stenting and/or surgery? Smelt J, Youssefi P, Soppa G, Jahangiri M. Journal of the Royal Society of Medicine, 2013;106(11):456-8.

20. Dilatation of the remaining aorta after aortic valve or aortic root replacement in patients with bicuspid aortic valve: A 5-year follow-up. Abdulkareem N, Soppa G, Jones S, Valencia O, Smelt J, Jahangiri M. The Annals of Thoracic Surgery, 2013 Jul;96(1):43-9.

21. Impact of European Society of Cardiology and European Association for Cardiothoracic Surgery Guidelines on Myocardial Revascularization on the activity of percutaneous coronary intervention and coronary artery bypass graft surgery for stable coronary artery disease. Yates MT, Soppa GK, Valencia O, Jones S, Firoozi S, Jahangiri M. The Journal of Thoracic and Cardiovascular Surgery, 2014; 147(2):606-10.

22. A woman with periodic chest pain. Patel AJ, Som R, Soppa GK, Smith EE. The BMJ, 2012; 345:e6869.

23. Expanding TAVI to younger lower risk patients? Jahangiri M, Soppa G. Letter to the Editor, The Journal of Thoracic and Cardiovascular Surgery, 2012; 144(2):522; author reply 523.

24. Heterotopic abdominal heart transplantation in rats for functional studies of ventricular unloading. Ibrahim M, Navaratnarajah M, Kukadia P, Rao C, Siedlecka U, Cartledge JE, Soppa GK, Van Doorn C, Yacoub MH, Terracciano CM. Journal of Surgical Research, 2013;179(1):e31-9.

25. Prolonged mechanical unloading affects cardiomyocyte excitation-contraction coupling, t-tubule and cell surface structure. Ibrahim M, Al Masri A, Navaratnarajah M, Siedlecka U, Soppa GK, Moshkov A, Al-Saud SA, Gorelik J, Yacoub MH, Terracciano CMN. FASEB J, 2010; 24(9):3321-9.

26. A gene expression profile of the myocardial response to clenbuterol. Lara-Pezzi E, Terracciano CMN, Soppa GK, Smolenski RT, Felkin LE, Yacoub MH, Barton PJR. Journal of Cardiovascular Translational Research, 2009; 2(2):191-7.

27. Adult Progenitor Cell Transplantation Influences Contractile Performance and Calcium Handling of Recipient Cardiomyocytes. Lee J, Fukushima S, Stagg MA, Soppa GK, Siedlecka U, Youssef S, Suzuki K, Yacoub MH, Terracciano CMN. American Journal of Physiology-Heart and Circulatory Physiology, 2009; 296(4):H927-36.

28. Identification of Cell-Specific Soluble Mediators and Cellular Targets during Cell Therapy for the Treatment of Heart Failure. Lee J, Stagg MA, Siedlecka U, Latif N, Soppa GK, Yacoub MH, Terracciano CMN. Regenerative Medicine, 2008; 3(6):953-62.

29. Cytoskeletal Protein 4.1R Affects Repolarisation and Regulates Calcium Handling in the Heart. Stagg MA, Carter E, Sohrabi N, Siedlecka U, Soppa GK, Mead F, Mohandas N, Taylor-Harris P, Baines A, Bennett P, Yacoub MH, Pinder JC, Terracciano CMN. Circulation Research, 2008; 103(8):855-63.

30. Effects of clenbuterol on contractility and Ca2+ homeostasis of isolated rat ventricular myocytes. Siedlecka U, Arora M, Kolettis T, Soppa GK, Lee J, Stagg M, Harding SE, Yacoub MH, Terracciano CMN. American Journal of Physiology-Heart and Circulatory Physiology, 2008; 295(5):H1917-26.

31. Direct effects of apelin on cardiomyocyte contractility and electrophysiology. Farkasfalvi K, Stagg MA, Coppen SR, Siedlecka U, Lee J, Soppa GK, Marczin N, Szokodi I, Yacoub MH, Terracciano CM. Biochemical and Biophysical Research Communications, 2007; 357(4):889-95.

32. The role of the cardiac Na/Ca exchanger in reverse remodelling: relevance for LVAD – recovery. Terracciano CMN, Koban M, Soppa GK, Siedlecka U, Lee J, Stagg MA, Yacoub MH. Annals of the New York Academy of Sciences, 2007; 1099:349-60.

Abstracts – Published as first author

1. Clenbuterol prevents Gαi protein reduction induced by mechanical unloading in failing cardiomyocytes. Soppa GKR, Latif, N., Lee, J, Stagg, M.A, Siedlecka, U, Yacoub, M.H. and Terracciano C.M.N., Journal of Molecular and Cellular Cardiology, Volume 42, Issue 6, Supplement 1, June 2007, Page S152.

2. Chronic clenbuterol treatment improves heart and myocyte function in heart failure, with and without mechanical unloading. Soppa GK, Lee J, Stagg MA, Youssef S, Siedlecka, U, Yacoub MH, Terracciano CM. Circulation 2006 October 31;114(18):483.

3. Influence of clenbuterol and unloading on myocardial cell contractile dysfunction and calcium homeostasis in early heart failure. Soppa G, Lee J, Stagg MA, Youssef S, Yacoub MH, Terracciano CMN. European Heart Journal 2006 August;27:408.

4. Chronic clenbuterol treatment improves heart and myocyte function in heart failure, with and without mechanical unloading. Soppa G, Lee J, Stagg M, Youssef S, Yacoub M, Terracciano C.. Journal of Molecular and Cellular Cardiology 2006 June;40(6):945.

5. Chronic administration of clenbuterol to mechanically unloaded, failing hearts affects calcium handling and myocyte function - Relevance to LVAD recovery. Soppa GK, Lee J, Stagg MA, Youssef S, Terracciano CMN, Yacoub MH. The Journal of Heart and Lung Transplantation. 2006 February; 25 (2S): S143.

6. Calcium handling in cardiomyocytes from mechanically unloaded, failing hearts - role of β2-adrenoceptor agonists. Soppa GKR, Lee J, Stagg MA, Youssef S, Terracciano CMN, Yacoub MH. 2006 Biophysical Society Meeting Abstracts. Biophysical Journal, Supplement, Abstract.

7. Effects of unloading and clenbuterol treatment on cell size and calcium handling in rat ventricular myocytes. Soppa GKR, Lee J, Stagg MA, Youssef S, Terracciano CMN, Yacoub MH. Biophysical Journal 2005 January;88(1):319A.

8. Chronic administration of clenbuterol affects ventricular myocyte size and calcium handling in rats. Soppa GK, Malik AH, Terracciano CM, Yacoub MH. Circulation 2003 October 28;108(17):331.

9. Predictive scoring system for sternal wound complications in adult cardiac surgery. Soppa GK, Nair SK, Jayakumar J, Valencia O, Gaer JA. Circulation 2002 October 15;106(16):E109.


Abstracts – Published as co-author

1. Outline of the principles of management of cardiac tumours. Gukop P, Valentia O, Soppa G, Momin A, Nowell J, Sarsam R, Chadrasekaran V, Jahangiri M. Journal of Cardiothoracic Surgery, 2015;10 Suppl 1:A166.

2. The effects of β2-adrenoceptor agonists on conduction velocity, field potentials and automaticity in cardiomyocytes. Stagg MA, Patel NG, Siedlecka U, Soppa GKR, Lee J, Yacoub MH and Terracciano CMN. Journal of Molecular and Cellular Cardiology, Volume 42, Issue 6, Supplement 1, June 2007, Page S25.

3. Clenbuterol affects rat ventricular myocyte contractility via an inhibitory G protein-mediated pathway. Siedlecka U, Arora M, Soppa GKR, Lee J, Stagg MA, Harding SE, Yacoub MH, Terracciano CMN. Journal of Molecular and Cellular Cardiology, Volume 42, Issue 6, Supplement 1, June 2007, Page S49.

4. Skeletal myoblasts and bone marrow cells enhance contractility of failing cardiomyocytes in co-culture. Lee, J, Siedlecka, U, Stagg, M.A, Soppa GKR, Yacoub, M.H. and Terracciano C.M.N. Journal of Molecular and Cellular Cardiology, Volume 42, Issue 6, Supplement 1, June 2007, Page S100.

5. Clenbuterol affects action potential morphology in failing rat hearts subjected to mechanical unloading. Stagg MA, Soppa GKR, Lee J, Siedlecka U, Kolettis TM, Yacoub MH, Terracciano CMN. Journal of Molecular and Cellular Cardiology (2007), doi: 10.1016/j.yjmcc.2007.03.811.

6. Clenbuterol, unlike other β2-adrenoceptor agonists, predominantly activates the Gi protein in isolated rat ventricular myocytes. Siedlecka U, Arora M, Soppa GK, Lee J, Farkasfalvi K, Stagg MA, Harding SE, Yacoub MH, Terracciano CMN. Circulation, Oct 2007; 116: II_549.

7. Effects Of Adult Progenitor Cell Transplantation On Unitary Sarcoplasmic Reticulum Calcium Release Events In Failing Recipient Cardiomyocytes. Stagg MA, Lee J, Siedlecka U, Soppa GK, Yacoub MH, Terracciano CMN. Circulation, Oct 2007; 116: II_592.

8. Cytoskeletal Protein 4.1R Affects Repolarisation And Regulates Calcium Handling In The Heart. Terracciano CMN, Sohrabi N, Siedlecka U, Stagg MA, Soppa GK, Lee J, Barton PJR, Bennett P, Pinder JC, Yacoub MH. Circulation, Oct 2007; 116: II_216 - II_217.

9. Paracrine effects of cell transplantation on recipient cardiomyocytes in a rat model of heart failure. Lee J, Fukushima S, Stagg MA, Soppa GK, Siedlecka U, Youssef S, Yacoub MH, Terracciano CM. European Heart Journal 2006 August;27:19.

10. Skeletal myoblasts and bone marrow-derived cells enhance the contractile function of isolated failing cardiomyocytes in co-culture. Lee J, Stagg MA, Soppa GK, Siedlecka U, Yacoub MH, Terracciano CM. Circulation 2006 October 31;114(18):93.

11. Oxidative capacity recovers in the unloaded heart with clenbuterol. Kalsi KK, Soppa GKR, Terracciano CMN, Smolenski RT, Yacoub MH. Journal of Molecular and Cellular Cardiology 2006 June;40(6):933.

12. The apelin-angiotensin receptor-like 1 (APJ) mRNA levels closely correlate with myocardial recovery in end-stage heart failure patients treated with left ventricular assist devices (LVADs). Felkin LE, Farkasfalvi K, Soppa GKR, Birks EJ, Marczin N, Barton PJR, Yacoub MH, Terracciano CMN. European Heart Journal 2006 August;27:267.

13. Matrix metalloproteinase (MMP) and tissue inhibitor of MMPs (TIMP) gene expression in myocardial recovery from heart failure. Felkin LE, Birks EJ, Soppa GK, Terracciano CM, Yacoub MH, Barton PJR. Heart 2006 February;92(2).

14. Paracrine Effects of Transplanted Bone Marrow Cells and Skeletal Myoblasts on Recipient Cardiomyocyte Function in a Rat Model of Heart Failure. Lee J, Fukushima S, Stagg MA, Soppa GK, Youssef S, Yacoub MH, Suzuki K, Terracciano CMN. The Journal of Heart and Lung Transplantation. 2006 February; 25 (2S): S152.

15. Transplantation of Bone Marrow Cells and Skeletal Myoblasts Affects Calcium Regulation of Recipient Ventricular Myocytes in a Rat Model of Heart Failure. Lee J, Fukushima S, Stagg MA, Soppa GK, Youssef S, Yacoub MH, Suzuki K, Terracciano CMN. 2006 Biophysical Society Meeting Abstracts. Biophysical Journal, Supplement, Abstract.

16. Direct effects of apelin, the ligand for the angiotensin receptor-like 1, on cardiomyocyte contractility and electrophysiology. Farkasfalvi K, Stagg MA, Siedlecka U, Lee J, Soppa GKR, Marczin N, Terracciano CMN. Journal of Molecular and Cellular Cardiology 2006 June;40(6):980.

17. Direct effects of apelin, the ligand for the angiotensin receptor-like 1, on cardiomyocyte contractility and electrophysiology. Farkasfalvi K, Stagg MA, Siedlecka U, Lee J, Soppa GKR, Marczin N, Terracciano CMN. European Heart Journal 2006 August;27:407.

18. The apelin receptor mRNA levels and myocardial recovery in end-stage heart failure patients treated with left ventricular assist devices (LVADs). Farkasfalvi K, Felkin L, Latif N, Soppa GK, George R, Birks E, Barton P, Marczin N, Yacoub MH, Terracciano CMN. Circulation 2006 October 31;114(18):484.

19. Apelin, the ligand for the angiotensin receptor-like 1, directly affects cardiomyocyte contractility and electrophysiology. Farkasfalvi K, Stagg MA, Siedlecka U, Lee J, Soppa GK, Marczin N, Szokodi I, Yacoub MH, Terracciano CMN. Circulation 2006 October 31;114(18):300.

20. Igf-1 transcription in cardiac myocytes and fibroblasts: Relevance to heart failure. Brand NJ, Barton PJR, Felkin LE, Clark LA, Chester AH, Soppa GK, Terracciano CMN, Lara-Pezzi E, Yacoub MH. Heart 2006 February;92(2).

21. β2-adrenoceptor signalling affects the sodium-calcium exchanger current in rat ventricular myocytes. Lee J, Stagg M, Soppa GK, Harding S, Terracciano CMN. Biophysical Journal 2005 January;88(1):136A.