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Liverpool Heart and Chest Hospital, Thomas Drive, L14 3PE
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Professor Dhiraj Gupta

Date: 30 September 2015 09:47


Personal Assistant

Sharon Ngai

0151 600 1251

Area of Practice

  • Electrophysiology
  • Left Atrial Appendage Occlusion

Special Clinical Interests

  • Catheter Ablation for Atrial Fibrillation
  • Stroke Prevention in Atrial Fibrillation
  • Left Atrial Appendage Occlusion

Research Interests

  • Improving Outcomes for Patients with Atrial Fibrillation

Regional and National responsibilities:

  • Honorary Treasurer, British Heart Rhythm Society: 2017-2018
  • Member of Council, British Heart Rhythm Society: 2015-2018
  • Member, Clinical Standards Committee, British Cardiovascular Society: 2017-date
  • Member, British Cardiac Intervention Society (BCIS) Structural Intervention Working Group: 2017-date
  • Member, Medical Advisory Committee, Atrial Fibrillation Association: 2014-date
  • Member, British Cardiovascular Society Finance Committee: June 2018-date

Current Membership of Professional Regional and National Bodies

  • Fellow of the Royal College of Physicians
  • Fellow of the European Society of Cardiology

Languages Spoken

  • English  

Professional Profile (including Training and Education)

  • Barts Hospital NHS Trust, London
  • St. Georges Hospital NHS Trust, London
  • All India Institute of Medical Sciences, New Delhi, India

About Dhiraj

I have been a very high-volume operator in interventional electrophysiology (EP) for over a decade, and have earned particular repute for my interventional management skills for Atrial Fibrillation (AF), the most common heart rhythm disorder. My success rates and safety record over the past decade have resulted in a large supra-regional referral practice.

I am the largest volume implanter for left atrial appendage occluder (LAAO) devices in the UK, and I proctor cardiologists extensively in UK, USA and Europe in this technique.

I have been awarded NHS local Clinical Excellence Awards in 2010, 2014 and 2015, and the national Bronze Clinical Excellence Award in 2017.

I have been successful in obtaining over £4million in competitive research grants, both from public grant bodies such as NIHR/ BHF as well as from industry, and am the Chief Investigator for several multicentre ablation clinical trials. I have supervised and examined PhD candidates for Imperial College London, University of Liverpool, Queen Mary University London, City University London, and University of Birmingham.   I have authored over 100 scientific publications and paper presentations, and my research has contributed to changes to recent international scientific guidelines and consensus statements.

Key Recent Publications 

  1. D Gupta, SH Chin. Bridging the Generation Gap in Atrial Fibrillation Ablation Technologies. JACC Clin Electrophysiol 2018;4:1566-68
  2. A Hussein, M Das, S Riva, M Morgan, C Ronayne, A Sahni, M Shaw, D Todd, M Hall, S Modi, A Natale, A Dello Russo, R Snowdon, D Gupta. Use of Ablation Index -guided ablation results in high rates of durable pulmonary vein isolation and freedom from arrhythmia in persistent AF: the PRAISE Study Results. Circ Arrhythm Electrophysiol 20182018;11:e006576
  3. CM Pearman, J Redfearn, E Williams, R Snowdon, P Modi, M Hall, S Modi, S Mahida, D Todd, N Mediratta, D Gupta.  Thoracoscopic vs. catheter ablation for atrial fibrillation during the institutional learning curve. Europace 2019: Feb 6. doi: 10.1093/europace/euy303
  4. B. Maille, A. Hussein, M. Das, V. Chaturvedi, M Shaw, M Morgan, C Ronayne, R Snowdon, D Gupta. Accuracy of left atrial bipolar voltages obtained by ConfiDENSE multielectrode mapping in patients with persistent atrial fibrillation.  J Cardiovasc Electrophysiol 2018; 29(6):881-888
  5. HR Khan, I Kralj-Hans, S Haldar, T Bahrami, J Clague, A De Souza, D Francis, W Hussain, J Jarman, DG Jones, N Mediratta, R Mohiaddin, T Salukhe, S Jones, J Lord, C Murphy, J Kelly, V Markides, D Gupta and T Wong.  Catheter Ablation versus Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation (CASA-AF): study protocol for a randomised controlled trial. Trials 2018; 19:117.https://doi.org/10.1186/s13063-018-2487-9
  6. A Verma, ACT Ha, P Kirchhof, G Hindricks, J S Healey, MD Hill, M Sharma, D. G Wyse, J Champagne, D Gupta, V Essebag, G Wells, D H Birnie. The Optimal Anti-Coagulation for Enhanced Risk Patients Post-Catheter Ablation for Atrial Fibrillation (OCEAN) trial. Am Heart J 2018 DOI 10.1016/j.ahj.2017.12.007
  7. D Gupta. Single procedure cure with atrial fibrillation ablation: may the force be with you. Europace 2018 Jan 9. doi: 10.1093/europace/eux364
  8. A Masoud, S Bartoletti, T Fairbairn, A Khurana, P Velavan, L Morrison A Khalatbari, S Aggarwal, N Sharma, P Kirchhof, D Gupta. Outcome of left atrial appendage occlusion in high risk patients. Heart 2018;104:594-9
  9. C Pearman, SS Poon, LJ Bonnett, S Haldar, T Wong, N Mediratta, D Gupta. Epicardial ablation alone vs. hybrid ablation for atrial fibrillation: A systematic review and meta-analysis. Arrhythmia Electrophysiology Review 2017;6(4):202-9
  10. M Das, D Tomlinson, D Gupta. Contact Force sensing catheters and increased risk of atrioesophageal fistula: is the tool to blame or the workmen? Heart Rhythm. 2017 Sep 13. pii: S1547-5271(17)31099-8. doi: 10.1016/j.hrthm.2017.09.020

  11. M Das, GJ Wynn, Y Saeed, S Gomes, M Morgan, C Ronayne, LBonnett, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Pulmonary Vein Isolation as a routine strategy regardless of symptoms: the PRESSURE randomised controlled trial. JACC Clin Electrophysiol 2017; 3:602-611
  12. D Gupta. Creating a quality radiofrequency ablation lesion: how difficult can that be? JACC Clin Electrophysiol 2017 https://doi.org/10.1016/j.jacep.2017.06.008
  13. A Hussein, M Das, V Chaturvedi, I K Asfour, N Daryanani, M Morgan, C Ronayne, M Shaw, R Snowdon, D Gupta. Prospective Use of Ablation Index Targets Improves Clinical Outcomes following Ablation for Atrial Fibrillation. J Cardiovasc Electrophysiol 2017; 28:1037-47. doi: 10.1111/jce.13281
  14. S Bartoletti, A Masoud, D Gupta. Left Atrial Appendage Occlusion with the Amulet Device Incomplete Occlusion, Thrombus Formation and the Importance of Intraprocedural Echocardiography JACC Clin Electrophysiol 2017:3:191
  15. GJ Wynn, MEL Kadri, I Haq, M Das, S Modi , RL Snowdon, M Hall, JEP Waktare, DM Todd, D Gupta.  Long term outcomes after ablation of persistent atrial fibrillation: an observational study over 6 years. Open Heart 2016; 3(2):e000394. doi: 10.1136/openhrt-2015-000394
  16. SS Poon, RM Cooper, D Gupta. Endocardial radiofrequency septal ablation-a new option for non surgical septal reduction in patients with hypertrophic obstructive cardiomyopathy (HOCM): a systematic review of clinical studies. Int J Cardiol 2016; 222:772-774
  17. M Das, JJ Loveday, GJ Wynn, S Gomes, Y Saeed, LBonnett, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Ablation Index, a novel marker of ablation lesion quality: prediction of pulmonary vein reconnection at repeat electrophysiology study and regional differences in target values. Europace 2017;19:775-783
  18. M Das, GJ Wynn, M Morgan, B Lodge, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Re-ablated sites of acute reconnection after pulmonary vein isolation do not predict sites of late reconnection at repeat electrophysiology study. J Cardiovasc Electrophysiol 2016;27: 381-9
  19. M Das, L Panter, G Wynn, N Connor, J Mills, P Kirchhof, D Gupta. Primary Care Atrial Fibrillation (PCAF) Service: Outcomes from Consultant-led anticoagulation assessment clinics in the Primary Care setting. BMJ Open 2015;5:e009267 doi:10.1136/bmjopen-2015-009267
  20. GJ Wynn, S Panniker, MCS Hall, RL Snowdon. JEP Waktare, V Markides, W Hussain, J Jarman, DM Todd, T Wong, D Gupta. Biatrial linear ablation in sustained non-permanent AF: Results of the Substrate Modification with Ablation and antiarrhythmic drugs in Non-Permanent Atrial Fibrillation Trial. Heart Rhythm 2016; 12:399-406
  21. M Das, GJ Wynn, M Morgan, B Lodge, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Recurrence of Atrial Tachyarrhythmia during the Second Month of the Blanking Period Predicts More Extensive Pulmonary Vein Reconnection at Repeat Electrophysiology Study. Circ Arrhythm Electrophysiol 2015: 8: 846-52
  22. GJ Wynn, M Das, LJ Bonnett, MCS Hall, RL Snowdon. JEP Waktare, S Modi, DM Todd, D Gupta.  A novel marker to predict early recurrence after atrial fibrillation ablation: The Ablation Effectiveness Quotient. J Cardiovasc Electrophysiol 2015; 26: 397-403
  23. Wynn GJ, Das M, Bonnett LJ, Gupta D. Quality-of-life benefits of catheter ablation of persistent atrial fibrillation: a reanalysis of data from the SARA study. Europace. 2015;17: 222-4
  24. Wynn GJ, Das M, Bonnett LJ, Panikker S, Wong T, Gupta D. Efficacy of Catheter Ablation for Persistent Atrial Fibrillation: A Systematic Review and Meta-Analysis of Evidence from Randomised and Non-Randomised Controlled Trials.  Circ Arrhythm Electrophysiol. 2014; 7: 841-52
  25. GJ Wynn, I Haq, J Hung, LJ Bonnett, G Lewis, M Webber, JEP Waktare, S Modi, RL Snowdon, MCS Hall, DM Todd, D Gupta.  Improving safety in catheter ablation for atrial fibrillation: a prospective study of the use of ultrasound to guide vascular access. J Cardiovasc Electrophysiol. 2014; 25(7): 680-5

26. GJ Wynn, DM Todd, M Webber, LJ Bonnett, J McShane, P Kirchhof, D Gupta. The European Heart Rhythm Association Symptom Classification for Atrial Fibrillation: Validation and Improvement through a Simple Modification. Europace 2014;16(7):965-72