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Professor Dhiraj Gupta

Date: 03 February 2022 03:59


Personal Assistant

Sharon Ngai

0151 600 1251

Area of Practice

  • Interventional Electrophysiology
  • Left Atrial Appendage Occlusion

Special Clinical Interests

  • Catheter Ablation for Atrial Fibrillation
  • Stroke Prevention in Atrial Fibrillation
  • Left Atrial Appendage Occlusion

Research Interests

  • Improving Outcomes for Patients with Atrial Fibrillation

Regional and National responsibilities:

  • Honorary Treasurer, British Heart Rhythm Society: 2017-2018
  • Member of Council, British Heart Rhythm Society: 2015-2018
  • Member, Clinical Standards Committee, British Cardiovascular Society: 2017-date
  • Member, British Cardiac Intervention Society (BCIS) Structural Intervention Working Group: 2017-2020
  • Member, Medical Advisory Committee, Atrial Fibrillation Association: 2014-date
  • Member, British Cardiovascular Society Finance Committee: June 2018-June 2021

Current Membership of Professional Regional and National Bodies

  • Fellow of the Royal College of Physicians
  • Fellow of the European Society of Cardiology

Languages Spoken

  • English  

Professional Profile (including Training and Education)

  • Barts Hospital NHS Trust, London
  • St. Georges Hospital NHS Trust, London
  • All India Institute of Medical Sciences, New Delhi, India

About Dhiraj

Professor Gupta has been a very high-volume operator in interventional electrophysiology (EP) since 2007, and has earned particular repute for his interventional management skills for Atrial Fibrillation (AF), the most common heart rhythm disorder. He is one of the largest volume implanters for left atrial appendage occluder (LAAO) devices in the UK, and he proctors cardiologists extensively in UK, USA and Europe in this technique.

Prof Gupta has been awarded NHS local Clinical Excellence Awards in 2010, 2014 and 2015, the national Bronze Clinical Excellence Award in 2016, and the national Silver Clinical Excellence Award in 2021.

Prof Gupta has authored over 100 peer-reviewed publications, is a popular speaker on the international scientific meeting circuit, and serves on the editorial board for several scientific journals. He has been successful in obtaining over £4million in competitive research grants, both from public grant bodies such as NIHR/ BHF as well as from industry, and he has served as the Chief Investigator for several multicentre ablation clinical trials. Prof Gupta has supervised and examined PhD candidates for Imperial College London, University of Liverpool, Queen Mary University London, City University London, and University of Birmingham.   

Key Recent Publications 

  1. WY Ding, N Kozhuharov, SH Chin, M Shaw, RL Snowdon, GYH. Lip, D Gupta. Feasibility of weight loss in obese atrial fibrillation patients attending a specialist arrhythmia clinic and its impact on ablation outcomes. J Arrhythmia 2020 DOI: 10.1002/joa3.12432
  2. WY Ding, D Gupta, GY Lip. Atrial fibrillation and the prothrombotic state: revisiting Virchow’s triad in 2020. Heart 2020 Jul 16;heartjnl-2020-316977. doi:10.1136/heartjnl-2020-316977
  3. D Gupta. Noninvasive assessment of durability of ablation lesions with magnetic resonance imaging: are we there yet? J Cardiovasc Electrophysiol 2020 July 9. doi:10.1111/jce.14661
  4. S Javed, D Gupta, GYH Lip. Atrial fibrillation in obesity: weighing up the evidence for catheter ablation. Clin Cardiol 2020 Jun 29. Doi:10.1002/clc.23416
  5. WY Ding, J Mandrola, D Gupta. Left atrial appendage occlusion: past, present and future. Thromb Haemost 2020 https://doi.org/0.1055/s-0040-1714654.
  6. SH Chin, J O’Brien, G Epicoco, P Peddinti, A Gupta, S Modi. J Waktare, R Snowdon, D Gupta. The Feasibility and Effectiveness of a Streamlined Single-Catheter Approach for Radiofrequency Atrial Fibrillation Ablation. J Arrhythmia 2020 DOI: 10.1002/joa3.12390
  7. GJ Wynn, J Andrade, D Gupta, R Whitlock. Propensity matched registry results: too good to be true? European Journal of Cardio-Thoracic Surgery 2020 (in press)
  8. M Duytschaever, J Vijgen, T De Potter, H Van Herendael, R Kobza, S Knecht, B Berte, P Taghji, J-P Albenque, B Zhang, D Gupta. Standardized Pulmonary Vein Isolation Workflow to Enclose Veins with Contiguous Lesions: The Multicenter VISTAX Trial. Europace. 2020 Nov 1;22(11):1645-1652
  9. N Kumar, M Ranganathan, S Mustafa, K Saraf, C Timmermans, D Gupta. Hemoptysis After Cryoablation for Atrial Fibrillation. J Atr Fibrillation 2019;12(4):2237
  10. WY Ding, E Williams, M Das, L Tovmassian, M Tayebjee, G Haywood, C Martin, K Rajappan, M Bates, IP Temple, T Reichlin, Z Chen, R Balasubramaniam, C Ronayne, N Clarkson, S Mahida, C Sticherling, D Gupta. Cryoballoon Pulmonary Vein Isolation as First Line Treatment for Typical Atrial Flutter (CRAFT): Study Protocol for a Randomised Controlled Trial. J Interv Card Electrophysiol 2020 May 8.doi: 10.1007/s10840-020-00746-6
  11. A Shantshila, D Gupta, GY Lip. Heart Rate Variability Changes Following Catheter Ablation for Atrial Fibrillation Kardiol Pol 2020;78(3):179-180
  12. EA Williams, V Russo, S Ceraso, D Gupta, R Barrett-Jolley. Anti-arrhythmic Properties of Non-Antiarrhythmic Medications. Pharmacol Res 2020 Jun;156:104762. doi: 10.1016/j.phrs.2020.104762
  13. WY Ding, S Harrison, D Gupta, GY Lip, DA Lane. Stroke and Bleeding Risk Assessments in Patients With Atrial Fibrillation: Concepts and Controversies. Front Med (Lausanne) 2020;7:54. doi: 10.3389/fmed.2020.00054
  14. S Javed, D Gupta, GY Lip. Obesity and Atrial Fibrillation: Making Inroads Through Fat. Eur Heart J Cardiovasc Pharmacother 2020 Feb 25;pvaa013.doi: 10.1093/ehjcvp/pvaa013
  15. D Gupta, TD Potter, T Disher, K Eaton, L Goldstein, L Patel, D Grima, M Velleca, G Costa. Comparative Effectiveness of Catheter Ablation Devices in the Treatment of Atrial Fibrillation: A Network Meta-Analysis.  Comp Eff Res 2020 Jan;9(2):115-126.doi: 10.2217/cer-2019-0165
  16. A Hussein, D Gupta, TD Potter, P Spin, K Eaton, L Goldstein, M Velleca, G Costa, D Grima, L patel, G Stabile. Treatment of Atrial Fibrillation Using Ablation Index-Guided Contact Force Ablation: A Matching-Adjusted Indirect Comparison to Cryoballoon Ablation. Adv Ther 2020 Feb;37(2):785-799. doi: 10.1007/s12325-019-01173-4
  17. S Bartoletti, M Mann, A Gupta, A Khan, A Sahni, M El Kadri, J Hobbs, S Modi, J Waktare, S Mahida, M Hall, R Snowdon, D Todd, D Gupta. Same-day Discharge in Selected Patients Undergoing Atrial Fibrillation Ablation. Pacing Clin Electrophysiol 2019;42(11):1448-1455.doi: 10.1111/pace.13807
  18. Maille, M. Das , A.Hussein, V.Chaturvedi, E.Williams, M.Shaw, M.Morgan, C.Ronayne, R.Snowdon, D Gupta. Reverse Remodelling of the Left Atrium after Pulmonary Vein Isolation for Persistent Atrial Fibrillation. J Interv Card Electrophysiol. 2019; 58(1):9-19
  19. CM Pearman, J Redfearn, E Williams, R Snowdon, P Modi, M Hall, S Modi, S Mahida, D Todd, N Mediratta, D Gupta. Thoracoscopic vs. catheter ablation for atrial fibrillation during the institutional learning curve. Europace. 2019 Feb 6. doi: 10.1093/europace/euy303
  20. D Gupta, SH Chin. Bridging the Generation Gap in Atrial Fibrillation Ablation Technologies. JACC Clin Electrophysiol 2018;4:1566-68
  21. WY Ding, A Khan, D Gupta, GY Lip. Short-term outcomes in newly diagnosed atrial fibrillation and chronic kidney disease: how important is ethnicity? J Am Heart Assoc 2019; doi:10.1161/JAHA.119.011953
  22. WY Ding, D Gupta, GY Lip. Physician estimation of thrombotic and bleeding risks in atrial fibrillation; let's talk about sex. Can J Cardiol 2019; doi: https://doi.org/10.1016/j.cjca.2018.12.011
  23. WY Ding, R Cooper, D Todd, D Gupta, M Hall, A Rao, J Wright, R Snowdon,J Waktare, S Modi. Natural progression of QRS duration in ICD-only patients. J Interv Card Electrophysiol 2018; 11(9):e006576
  24. G Wynn, D Gupta, B Maille, R Snowdon, J Waktare, D odd, M Hall, S Mahida, S Modi. Demonstration of Pulmonary Vein Exit Block following Pulmonary Vein Isolation: A Novel Use for Adenosine. J Cardiovasc Electrophysiol 2018: 29(11): 1493-99
  25. C Pius, B Maille, D Gupta, S Modi. Further Evidence of Tricuspid Isthmus ‘Muscle Bundles’ using Rhythmia Mapping technology. JACC Clin Electrophysiol 2018; 4(8):1119-1120
  26. JM Mandrola, D Gupta. What Is the Role of Ablation for AF in a Post-CABANA World? Commentary. Heart.org on Medscape. 21 May 2018. https://medscape.com/viewarticle/896837
  27. A Hussein, M Das, S Riva, M Morgan, C Ronayne, A Sahni, M Shaw, D Todd, M Hall, S Modi, A Natale, A Dello Russo, R Snowdon, D Gupta. Use of Ablation Index-guided ablation results in high rates of durable pulmonary vein isolation and freedom from arrhythmia in persistent AF: the PRAISE Study Results. Circ Arrhythm Electrophysiol 20182018;11:e00657
  28. C Pearman, D Gupta. Authors Reply: Hybrid Approach for Atrial Fibrillation Ablation: the jury is still out. Arrhythmia Electrophysiology Review 2018;7(1):65-66
  29. Hernández-Madrid A, Paul T, Abrams D, Aziz PF, Blom NA, Chen J, Chessa M, Combes N, Dagres N, Diller G, Ernst S, Giamberti A, Hebe J, Janousek J, Kriebel T, Moltedo J, Moreno J, Peinado R, Pison L, Rosenthal E, Skinner JR, Zeppenfeld K; ESC Scientific Document Group. D Gupta Document reviewer. Arrhythmias in congenital heart disease: a position paper of the European Heart Rhythm Association (EHRA), Association for European Paediatric and Congenital Cardiology (AEPC), and the European Society of Cardiology (ESC) Working Group on Grown-up Congenital heart disease, endorsed by HRS, PACES, APHRS, and SOLAECE. Europace 2018 Mar 20. doi: 10.1093/europace/eux380
  30. Maille, A. Hussein, M. Das, V. Chaturvedi, M Shaw, M Morgan, C Ronayne, R Snowdon, D Gupta. Accuracy of left atrial bipolar voltages obtained by ConfiDENSE multielectrode mapping in patients with persistent atrial fibrillation. J Cardiovasc Electrophysiol 2018; 29(6):881-888
  31. HR Khan, I Kralj-Hans, S Haldar, T Bahrami, J Clague, A De Souza, D Francis, W Hussain, J Jarman, DG Jones, N Mediratta, R Mohiaddin, T Salukhe, S Jones, J Lord, C Murphy, J Kelly, V Markides, D Gupta and T Wong. Catheter Ablation versus Thoracoscopic Surgical Ablation in Long Standing Persistent Atrial Fibrillation (CASA-AF): study protocol for a randomised controlled trial. Trials 2018; 19:117.https://doi.org/10.1186/s13063-018-2487-9
  32. CM Pearman, W Ding, D Gupta, S Modi. A classic textbook flutter. Pacing Clin Electrophysiol. 2017 Nov 30. doi: 10.1111/pace.13243
  33. D Gupta, A Masoud, S Bartoletti. The role of left atrial appendage occlusion in high- risk patients needs to be better defined. Heart 2018;104:624. doi:10.1136/heartjnl- 2017-312829
  34. A Verma, ACT Ha, P Kirchhof, G Hindricks, J S Healey, MD Hill, M Sharma, D. G Wyse, J Champagne, D Gupta, V Essebag, G Wells, D H Birnie. The Optimal Anti- Coagulation for Enhanced Risk Patients Post-Catheter Ablation for Atrial Fibrillation (OCEAN) trial. Am Heart J 2018 DOI 10.1016/j.ahj.2017.12.007
  35. D Gupta. Single procedure cure with atrial fibrillation ablation: may the force be with you. Europace 2018 Jan 9. doi: 10.1093/europace/eux364
  36. A Masoud, S Bartoletti, T Fairbairn, A Khurana, P Velavan, L Morrison A Khalatbari, S Aggarwal, N Sharma, P Kirchhof, D Gupta. Outcome of left atrial appendage occlusion in high risk patients. Heart 2018;104:594-9
  37. C Pearman, SS Poon, LJ Bonnett, S Haldar, T Wong, N Mediratta, D Gupta. Epicardial ablation alone vs. hybrid ablation for atrial fibrillation: A systematic review and meta-analysis. Arrhythmia Electrophysiology Review 2017;6(4):202-9
  38. M Das, D Tomlinson, D Gupta. Contact Force sensing catheters and increased risk of atrioesophageal fistula: is the tool to blame or the workmen? Heart Rhythm. 2017 Sep 13. pii: S1547-5271(17)31099-8. doi: 10.1016/j.hrthm.2017.09.020
  39. Huisman MV, Rothman KJ, Paquette M, Teutsch C, Diener HC, Dubner SJ, Halperin JL, Ma CS, Zint K, Elsaesser A, Bartels DB, Lip GY; GLORIA-AF Investigators. The Changing Landscape for Stroke Prevention in AF: Findings from the GLORIA AF Registry Phase 2. J Am Coll Cardiol. 2017 Feb 21;69(7):777-785
  40. M Das, GJ Wynn, Y Saeed, S Gomes, M Morgan, C Ronayne, LBonnett, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Pulmonary Vein Isolation as a routine strategy regardless of symptoms: the PRESSURE randomised controlled trial. JACC Clin Electrophysiol 2017; 3:602-611
  41. D Gupta. Creating a quality radiofrequency ablation lesion: how difficult can that be? JACC Clin Electrophysiol 2017 https://doi.org/10.1016/j.jacep.2017.06.008
  42. Chaturvedi V, Maille B, Gupta D. Bipolar Voltage Analysis with Multi-electrode Mapping. J Cardiovasc Electrophysiol 2017 doi: 10.1111/jce.13238
  43. A Hussein, M Das, V Chaturvedi, I K Asfour, N Daryanani, M Morgan, C Ronayne, M Shaw, R Snowdon, D Gupta. Prospective Use of Ablation Index Targets Improves Clinical Outcomes following Ablation for Atrial Fibrillation. J Cardiovasc Electrophysiol 2017; 28:1037-47. doi: 10.1111/jce.13281
  44. SS Poon, M Field, D Gupta, D Cameron. Surgical septal myectomy or alcohol septal ablation: which approach offers better outcomes for patients with hypertrophic obstructive cardiomyopathy? Interactive Cardiovascular and Thoracic Surgery 2017. DOI: 10.1093/icvts/ivx001
  45. S Bartoletti, A Masoud, D Gupta. Left Atrial Appendage Occlusion with the Amulet Device Incomplete Occlusion, Thrombus Formation and the Importance of Intraprocedural Echocardiography JACC Clin Electrophysiol 2017:3:191
  46. SK Haldar, DG Jones, H Khan, S Panikker, JWE Jarman, C Butcher, E Lim, G Wynn, D Gupta, W Hussain, V Markides, and T Wong. Characterising the difference in electrophysiological substrate and outcomes between heart failure and non-heart failure patients with persistent atrial fibrillation. Europace 2017 Jan 20. pii: euw380
  47. GJ Wynn, MEL Kadri, I Haq, M Das, S Modi , RL Snowdon, M Hall, JEP Waktare, DM Todd, D Gupta. Long term outcomes after ablation of persistent atrial fibrillation: an observational study over 6 years. Open Heart 2016; 3(2):e000394. doi: 10.1136/openhrt-2015-000394
  48. SS Poon, RM Cooper, D Gupta. Endocardial radiofrequency septal ablation-a new option for non surgical septal reduction in patients with hypertrophic obstructive cardiomyopathy (HOCM): a systematic review of clinical studies. Int J Cardiol 2016; 222:772-774
  49. S Bartoletti, S Parikh, D Gupta. Letter by Bartoletti et al regarding article, ‘Ablation of Persistent Atrial Fibrillation Targeting Low Voltage Areas with selective Activation Characteristics’. Circ Arrhythm Electrophysiol 2016; 9(7). Pii:e004302
  50. M Das, JJ Loveday, GJ Wynn, S Gomes, Y Saeed, LBonnett, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Ablation Index, a novel marker of ablation lesion quality: prediction of pulmonary vein reconnection at repeat electrophysiology study and regional differences in target values. Europace 2017;19:775-783
  51. W Ullah, A McLean, M Tayabjee, D Gupta, MR Ginks, GA Haywood, M O’Neill, PD Lambiase, MJ Earley, RJ Schilling. Randomised trial comparing pulmonary vein isolation using the SmartTouch catheter with or without real-time contact force data. Heart Rhythm 2016; 13(9):1761-7
  52. JM Mandrola, D Gupta. Cardiostim: Left Atrial Appendage Occlusion Done the Right Way. Commentary. Heart.org on Medscape. 09 June 2016. https://medscape.com/viewarticle/864579
  53. M Das, GJ Wynn, M Morgan, B Lodge, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Re-ablated sites of acute reconnection after pulmonary vein isolation do not predict sites of late reconnection at repeat electrophysiology study. J Cardiovasc Electrophysiol 2016;27: 381-9
  54. M Das, L Panter, G Wynn, N Connor, J Mills, P Kirchhof, D Gupta. Primary Care Atrial Fibrillation (PCAF) Service: Outcomes from Consultant-led anticoagulation assessment clinics in the Primary Care setting. BMJ Open 2015;5:e009267 doi:10.1136/bmjopen-2015-009267
  55. GJ Wynn, S Panniker, MCS Hall, RL Snowdon. JEP Waktare, V Markides, W Hussain, J Jarman, DM Todd, T Wong, D Gupta. Biatrial linear ablation in sustained non-permanent AF: Results of the Substrate Modification with Ablation and antiarrhythmic drugs in Non-Permanent Atrial Fibrillation Trial. Heart Rhythm 2016; 12:399-406
  56. M Das, GJ Wynn, M Morgan, B Lodge, JEP Waktare, DM Todd, MCS Hall, RL Snowdon, S Modi, D Gupta. Recurrence of Atrial Tachyarrhythmia during the Second Month of the Blanking Period Predicts More Extensive Pulmonary Vein Reconnection at Repeat Electrophysiology Study. Circ Arrhythm Electrophysiol 2015: 8: 846-52
  57. GJ Wynn, M Das, LJ Bonnett, MCS Hall, RL Snowdon. JEP Waktare, S Modi, DM Todd, D Gupta. A novel marker to predict early recurrence after atrial fibrillation ablation: The Ablation Effectiveness Quotient. J Cardiovasc Electrophysiol 2015; 26: 397-403
  58. Cardiac Arrest in athletes and resuscitation. PB Bapat, A Bapat, D Gupta. J Intensive Care Soc 2015; 16: 85-86
  59. Relationship between Contact Force Sensing Technology and Medium Term Outcome of Atrial Fibrillation Ablation: A Multicenter Study of 600 Patients. Jarman JW, Panikker S, Das M, Wynn GJ, Ullah W, Kontogeorgis A, Haldar SK, Patel PJ, Hussain WJ, Markides V, Gupta D, Schilling RJ, Wong T. J Cardiovasc Electrophysiol 2015; 26: 378-84
  60. Wynn GJ, Das M, Bonnett LJ, Gupta D. Quality-of-life benefits of catheter ablation of persistent atrial fibrillation: a reanalysis of data from the SARA study. Europace. 2015;17: 222-4
  61. Wynn GJ, Das M, Bonnett LJ, Panikker S, Wong T, Gupta D. Efficacy of Catheter Ablation for Persistent Atrial Fibrillation: A Systematic Review and Meta-Analysis of Evidence from Randomised and Non-Randomised Controlled Trials. Circ Arrhythm Electrophysiol. 2014; 7: 841-52
  62. GJ Wynn, I Haq, J Hung, LJ Bonnett, G Lewis, M Webber, JEP Waktare, S Modi, RL Snowdon, MCS Hall, DM Todd, D Gupta. Improving safety in catheter ablation for atrial fibrillation: a prospective study of the use of ultrasound to guide vascular access. J Cardiovasc Electrophysiol. 2014; 25(7): 680-5
  63. GJ Wynn, DM Todd, M Webber, LJ Bonnett, J McShane, P Kirchhof, D Gupta. The European Heart Rhythm Association Symptom Classification for Atrial Fibrillation: Validation and Improvement through a Simple Modification. Europace 2014;16(7):965-72